Une collaboration internationale met en lumière une nouvelle cible thérapeutique pour le syndrome de l’X fragile

An international collaboration involving the late UdeM neuroscientist highlights a new therapeutic target for Fragile X syndrome, a leading cause of autism and intellectual disability.

Preclinical study in mice finds blocking specific brain protein can improve brain function and behavior

The study finds people with fragile X syndrome have sensory signals coming from the external world are under-represented in the brain, the opposite of what they expected.

Il semblerait que certains signaux ne prennent pas suffisamment de place dans le cerveau des enfants qui présentent la forme la plus courante d'autisme, alors qu'on supposait jusqu'à maintenant qu'ils en prenaient trop.

Une découverte réalisée par un chercheur du CHU Sainte-Justine pourrait venir complètement chambouler la compréhension qu’ont les experts de la forme la plus courante d’autisme.

Une découverte réalisée par un chercheur du CHU Sainte-Justine pourrait venir complètement chambouler la compréhension qu’ont les experts de la forme la plus courante d’autisme.

The study was published on January 3 in the prestigious journal Proceedings of the National Academy of Sciences.

Des neuroscientifiques ont démontré que dans le syndrome de l'X fragile, la cause la plus fréquente de l’autisme, les signaux sensoriels du monde extérieur sont intégrés différemment.

Researchers at the CHU Sainte-Justine Research Centre show that in Fragile X syndrome, the most common cause of autism, sensory signals from the outside world are underrepresented

Cette découverte ouvre la porte à de nouvelles thérapies pour aider les personnes atteintes du syndrome de l’X fragile à percevoir correctement les signaux du monde extérieur

Peer-Reviewed Publication. UNIVERSITY OF MONTREAL

This finding opens the door to new strategies to offer support to those with FXS and possibly other autism spectrum disorders to correctly perceive sensory signals from the outside world at the level of pyramidal neurons in the cortex.

The study revealed that sensory signals from the outside world are integrated differently in Fragile X syndrome (FXS), the most prevalent cause of autism, resulting in them being underrepresented by cortical pyramidal neurons in the brain.

In fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain

Environmental sensory signals are integrated differently in those with Fragile X syndrome, causing them to be underrepresented by cortical pyramidal neurons.

In Fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain.

In Fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain.

Here, researchers show that when inputs are clustered in space, the plasticity rule changes, favouring increases in synaptic strength.

Using advanced techniques in two-photon microscopy that mimic synaptic contacts between two neurons, the researchers discovered an important law related to the arrangement of information received by dendritic spines.

Une meilleure compréhension de la fonction des épines dendritiques et de leurs effets sur les apprentissages et la mémoire nourrirait l’espoir de développer de nouvelles approches thérapeutiques notamment contre l’Alzheimer, les anomalies au niveau des épines dendritiques n’étant pas étrangères à ce type de démence.

Using these techniques, they found that nerve cells perceive and store information differently, depending on the number and physical proximity of the inputs they receive.

A Canadian research team highlights the mechanisms underlying memory and learning capacity – specifically, how our brains process, store and integrate information.

La memoria se procesa en un árbol de neuronas de la corteza cerebral que amplifican la información relevante y silencian la innecesaria mediante leyes que regulan lo que aprendemos o recordamos

"Describimos la minima unidad funcional de la memoria que despues nos servira para construir el edificio completo de nuestras memorias.

Researchers at CHU Sainte-Justine Hospital and Université de Montréal have made a major discovery in understanding the mechanisms underlying learning and memory formation.

Until now, no one knew how synaptic inputs (incoming information) were arranged in the ‘neural tree’ and what precisely causes a dendritic spine to increase or decrease the strength, or loudness, of information it passes on

A research team highlights the mechanisms underlying memory and learning capacity—specifically, how our brains process, store and integrate information.

Entender el funcionamiento de la mente humana convoca a científicos e investigadores. Y descifrar interrogantes sobre cómo se forjan los recuerdos y funciona biológicamente la memoria es un desafío monumental.

Jusqu’à présent, personne ne savait comment l’information était agencée dans l’“arbre neuronal” et ce qui incitait précisément une épine dendritique à augmenter ou à baisser le volume de l’information